Staff Scientist I, Research Cores

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Overview
 

Are you passionate about translational biomedical research and scientific discovery? Interested in working in a dynamic, industry-inspired environment at the interface of academia and biotechnology? The Yale Center for Molecular Discovery (YCMD), a university-wide core facility within Yale School of Medicine, is seeking a highly motivated Staff Scientist I to support innovative research programs in high-throughput assay development, genomic screening, and early-stage drug and probe discovery.

YCMD provides investigators across Yale with access to specialized expertise in assay development, laboratory automation, chemical and genomic screening, and quantitative data analysis. The successful candidate will contribute intellectual and technical expertise to a diverse portfolio of projects spanning basic, translational, and therapeutic discovery research. Because YCMD supports a broad range of biological applications and disease areas, candidates with multidisciplinary scientific backgrounds and a strong interest in collaborative research are encouraged to apply.

The Staff Scientist I will:

• Lead and support high-throughput assay development and screening projects. Working independently and in collaboration with senior YCMD personnel, engage with investigators to define project goals and scope, evaluate experimental strategies, develop project plans, design and execute biochemical, cellular, and imaging-based assays, perform screening campaigns, analyze data, prepare reports, and recommend follow-up and validation studies.

• Maintain accurate and timely documentation of research activities. Present project updates at internal team meetings, communicate results to collaborators, prepare technical reports, and assist investigators in defining next-stage research objectives.

• Contribute to YCMD infrastructure development and daily laboratory operations. Operate, maintain, and troubleshoot advanced screening, automation, and imaging instrumentation; collaborate with vendors and service providers; and participate in technology evaluation, implementation, and process-improvement initiatives.

• Build and maintain productive relationships with investigators and collaborators within Yale and external organizations. Manage multiple concurrent projects while working effectively both independently and as part of multidisciplinary scientific teams. Contribute scientific data, analyses, and technical expertise to grant applications, publications, presentations, and other scholarly activities that advance the research mission of Yale University.

• Serve as a scientific resource for Yale researchers by providing expertise in high-throughput screening, assay development, genomic screening technologies, and approaches to chemical and genetic probe discovery. Participate in training, educational, and mentorship activities supported by the Center.

Required Skills and Abilities

1. Demonstrated ability to work independently and collaboratively within multidisciplinary teams to support and manage scientific projects, develop experimental strategies, and execute complex research programs.

2. Ability to quickly learn and implement new technologies and methodologies.

3. Excellent organizational, communication, and interpersonal skills, with the ability to prioritize competing demands and effectively manage multiple concurrent research and infrastructure projects.

4. Strong foundation in molecular biology, cell biology, and related biomedical disciplines.

5. Strong analytical and problem-solving skills with the ability to interpret experimental data, troubleshoot technical challenges, and communicate scientific findings.

Preferred Skills and Abilities

1. M.S. degree in Biology, Biochemistry, Molecular Biology, Pharmacology, Biomedical Sciences, or a related field, with at least two years of research experience in an academic, biotechnology, or pharmaceutical setting.

2. Proven experience working in a research core facility, shared-resource environment, contract research organization (CRO), or similar service-oriented scientific setting.

3. Proven experience with laboratory automation, liquid handling systems, high throughput screening (HTS), genomic screening technologies, recombinant protein production and characterization, microscopy, and image analysis workflows.

4. Proven experience applying statistical and computational approaches to the analysis of large-scale biological datasets and screening experiments. Proficiency with scientific software packages for data analysis, visualization, and statistical evaluation.

5. Demonstrated record of scientific productivity, including contributions to publications, presentations, grant applications, or collaborative research projects.

Principal Responsibilities

1. User Training: Provide technical training and guidance to users of the research core. 2. Experiment Support: Contribute to experimental design, execution, data analysis, and troubleshooting for research projects using established protocols within the research core. 3. Facility/Instrument Support: Support research core operations, including specialized equipment maintenance.  4. Technique Development: Optimize experimental protocols and workflows. 5. Data Analysis/Interpretation: Analyze and interpret complex scientific data. 6. Equipment Procurement: Assist in the installation and maintenance of specialized research core equipment. 7. Professional Development: Stay updated with relevant scientific literature and advancements in the field. Participate in professional development activities and scientific conferences. 8. Scientific Participation: Collect and analyze scientific data for manuscript preparation and grant proposals 9. Vendor Relations: Maintains vendor relationships, evaluates products, and collaborates with purchasing for timely procurement of laboratory supplies. 10. Education and Outreach: Participate in education and outreach activities within the core, including tours, events, etc. Required Education and Experience Bachelor’s degree in a related discipline and two years of related experience or an equivalent combination of skills, education, and experience

Job Posting Date

07/14/2026

Job Category

Professional

Bargaining Unit

NON

Compensation Grade

Administration & Operations

Compensation Grade Profile

Associate (22)

Salary Range

$61,500.00 - $91,875.00

Time Type

Full time

Duration Type

Staff

Work Model

On-site

Background Check Requirements

All candidates for employment will be subject to pre-employment background screening for this position, which may include motor vehicle, DOT certification, drug testing and credit checks based on the position description and job requirements. All offers are contingent upon the successful completion of the background check. For additional information on the background check requirements and process visit "Learn about background checks" under the Applicant Support Resources section of Careers on the It's Your Yale website.

Health Requirements

Certain positions have associated health requirements based on specific job responsibilities. These may include vaccinations, tests, or examinations, as required by law, regulation, or university policy.

Posting Disclaimer

Salary offers are determined by a candidate’s qualifications, experience, skills, and education in relation to the position requirements, along with the role’s grade profile and current internal and external market conditions.

The intent of this job description is to provide a representative summary of the essential functions that will be required of the position and should not be construed as a declaration of specific duties and responsibilities of the position. Employees will be assigned specific job-related duties through  their hiring department.

The University is committed to basing judgments concerning the admission, education, and employment of individuals upon their qualifications and abilities and seeks to attract to its faculty, staff, and student body qualified persons from a broad range of backgrounds and perspectives. In accordance with this policy and as delineated by federal and Connecticut law, Yale does not discriminate in admissions, educational programs, or employment against any individual on account of that individual’s sex, sexual orientation, gender identity or expression, race, color, national or ethnic origin, religion, age, disability, status as a special disabled veteran, veteran of the Vietnam era or other covered veteran.

Inquiries concerning Yale's Policy Against Discrimination and Harassment may be referred to the Office of Institutional Equity and Accessibility (OIEA).

Note

Yale University is a tobacco-free campus.